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• Isavuconazole, a novel broad-spectrum antifungal, is being developed for the treatment of severe invasive fungal infections and has the potential to become the best-in-class azole. The water-soluble compound can be administered intravenously or orally. The investigational drug has received fast track status from the FDA and is in clinical phase III development. Basilea Pharmaceutica International Ltd. has entered into a license, co-development and co-promotion agreement with Astellas Pharma Inc. for isavuconazole for the treatment of life-threatening invasive fungal infections.
• Ceftobiprole is a broad-spectrum anti-MRSA antibiotic belonging to the cephalosporin class for the treatment of potentially life-threatening resistant bacterial infections. Its broad spectrum activity, which encompasses Gram-positive and Gram-negative bacteria, including anti-pseudomonal activity similar to cefepime, suggests the potential for empirical monotherapy for complicated skin and skin structure infections as well as healthcare-associated pneumonia. The rights for ceftobiprole have been transferred back to Basilea from Cilag GmbH International, a Johnson & Johnson company, in February 2011.
• BAL30072, a novel sulfactam antibiotic, has potent antimicrobial activity against a broad range of multidrug-resistant Gram-negative bacteria, including Pseudomonas aeruginosa, Acinetobacter spp., Klebsiella spp. and Enterobacter spp., that are increasingly associated with potentially life-threatening infections in hospitals around the world. The clinical phase I program is ongoing.
• BAL101553 is the highly water-soluble prodrug of BAL27862, a novel synthetic small-molecule drug that has demonstrated anti-cancer activity across a broad panel of solid tumor models, including those resistant against agents such as taxanes or Vinca alkaloids. The clinical phase I program is ongoing.
• Preclinical programs: Basilea pursues research programs in lead optimization as well as early stages of discovery.
• Toctino® (alitretinoin) was developed and brought to market by Basilea. Basilea entered into a global agreement on Toctino® with Stiefel, a GSK company, in June 2012.
  
  

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